Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models

Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models

Parabens are alkyl esters of 4-hydroxybenzoic acid (4-HBA), with short-chain parabens used as antimicrobials in cosmetics. We investigated the influence of chain construction on skin and liver metabolism. Incubations with main human hepatocytes and human liver S9 indicated that methyl-, ethyl-, propyl- and butylparaben have been quickly metabolized to comparable metabolites, together with 4-HBA plus …

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