Isogenic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model

Isogenic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model

Rett syndrome (RTT) is an autism spectrum developmental dysfunction attributable to mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene. Excellent RTT mouse fashions have been created to review the disease mechanisms, resulting in many vital findings with potential therapeutic implications. These embrace the identification of many MeCP2 goal genes, higher understanding of the neurobiological penalties of the …

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