MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome

Citramalate synthase yields a biosynthetic pathway for isoleucine and straight- and branched-chain ester formation in ripening apple fruit

Citramalate synthase yields a biosynthetic pathway for isoleucine and straight- and branched-chain ester formation in ripening apple fruit

A plant pathway that initiates with the formation of citramalate from pyruvate and acetyl-CoA by citramalate synthase (CMS) is proven to contribute to the synthesis of α-ketoacids and vital odor-active esters in apple (Malus × domestica) fruit. Microarray screening led to the invention of a gene with excessive amino acid similarity to 2-isopropylmalate synthase (IPMS). However, practical …

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Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models

Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models

Parabens are alkyl esters of 4-hydroxybenzoic acid (4-HBA), with short-chain parabens used as antimicrobials in cosmetics. We investigated the influence of chain construction on skin and liver metabolism. Incubations with main human hepatocytes and human liver S9 indicated that methyl-, ethyl-, propyl- and butylparaben have been quickly metabolized to comparable metabolites, together with 4-HBA plus …

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Tracer movements in a straight uniform flow: New equations for the advective part considering the distortion of flow lines around the well

Tracer movements in a straight uniform flow: New equations for the advective part considering the distortion of flow lines around the well

Methods for decoding tracer assessments usually depend on equations assuming a pure regional flow which is straight and uniform. The most important goal of this undertaking was to develop extra reasonable equations for the advective part of contaminant transport, by together with the flow lines distortion occurring in the neighborhood of the injection well. The …

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MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome

MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome

Epigenetic mechanisms, such as DNA methylation, regulate transcriptional programs to afford the genome flexibility in responding to developmental and environmental cues in health and disease. A prime example involving epigenetic dysfunction is the postnatal neurodevelopmental disorder Rett syndrome (RTT), which is caused by mutations in the gene encoding methyl-CpG binding protein 2 (MeCP2). Despite decades of research, it remains unclear …

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