Vera Ross

The Comparative Methylome and Transcriptome After Change of Direction Compared to Straight Line Running Exercise in Human Skeletal Muscle

The Comparative Methylome and Transcriptome After Change of Direction Compared to Straight Line Running Exercise in Human Skeletal Muscle

The methylome and transcriptome signatures following train which can be physiologically and metabolically related to sporting contexts akin to workforce sports activities or well being prescription situations (e.g., excessive depth interval coaching/HIIT) has not been investigated. To discover this, we carried out two completely different sport/train related high-intensity operating protocols in 5 male sport workforce …

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Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models

Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models

Parabens are alkyl esters of 4-hydroxybenzoic acid (4-HBA), with short-chain parabens used as antimicrobials in cosmetics. We investigated the influence of chain construction on skin and liver metabolism. Incubations with main human hepatocytes and human liver S9 indicated that methyl-, ethyl-, propyl- and butylparaben have been quickly metabolized to comparable metabolites, together with 4-HBA plus …

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Tracer movements in a straight uniform flow: New equations for the advective part considering the distortion of flow lines around the well

Tracer movements in a straight uniform flow: New equations for the advective part considering the distortion of flow lines around the well

Methods for decoding tracer assessments usually depend on equations assuming a pure regional flow which is straight and uniform. The most important goal of this undertaking was to develop extra reasonable equations for the advective part of contaminant transport, by together with the flow lines distortion occurring in the neighborhood of the injection well. The …

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Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept.

Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept.

Geriatricians have embraced the time period “geriatric syndrome,” utilizing it extensively to focus on the distinctive options of widespread well being circumstances in older folks. Geriatric syndromes, similar to delirium, falls, incontinence, and frailty, are extremely prevalent, multifactorial, and related to substantial morbidity and poor outcomes. Nevertheless, this central geriatric idea has remained poorly outlined. …

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Twenty years of research on cytokine-induced sickness behavior.

Cytokine-induced sickness habits was acknowledged inside a couple of years of the cloning and expression of interferon-alpha, IL-1 and IL-2, which occurred across the time that the primary challenge of Brain, Behavior, and Immunity was printed in 1987. Phase I scientific trials established that injection of recombinant cytokines into most cancers sufferers led to a …

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Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration.

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration.

Cerebral small vessel disease (SVD) is a standard accompaniment of ageing. Features seen on neuroimaging embrace current small subcortical infarcts, lacunes, white matter hyperintensities, perivascular areas, microbleeds, and mind atrophy. SVD can current as a stroke or cognitive decline, or can have few or no signs. SVD ceaselessly coexists with neurodegenerative disease, and can exacerbate …

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Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

This review summarizes evidence of dysregulated reward circuitry function in a range of neurodevelopmental and psychiatric disorders and genetic syndromes. First, the contribution of identifying a core mechanistic process across disparate disorders to disease classification is discussed, followed by a review of the neurobiology of reward circuitry. We next consider preclinical animal models and clinical evidence of reward-pathway …

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MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome

MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome

Epigenetic mechanisms, such as DNA methylation, regulate transcriptional programs to afford the genome flexibility in responding to developmental and environmental cues in health and disease. A prime example involving epigenetic dysfunction is the postnatal neurodevelopmental disorder Rett syndrome (RTT), which is caused by mutations in the gene encoding methyl-CpG binding protein 2 (MeCP2). Despite decades of research, it remains unclear …

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Isogenic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model

Isogenic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model

Rett syndrome (RTT) is an autism spectrum developmental dysfunction attributable to mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene. Excellent RTT mouse fashions have been created to review the disease mechanisms, resulting in many vital findings with potential therapeutic implications. These embrace the identification of many MeCP2 goal genes, higher understanding of the neurobiological penalties of the …

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