Month: March 2021

Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models

Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models

Parabens are alkyl esters of 4-hydroxybenzoic acid (4-HBA), with short-chain parabens used as antimicrobials in cosmetics. We investigated the influence of chain construction on skin and liver metabolism. Incubations with main human hepatocytes and human liver S9 indicated that methyl-, ethyl-, propyl- and butylparaben have been quickly metabolized to comparable metabolites, together with 4-HBA plus …

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Tracer movements in a straight uniform flow: New equations for the advective part considering the distortion of flow lines around the well

Tracer movements in a straight uniform flow: New equations for the advective part considering the distortion of flow lines around the well

Methods for decoding tracer assessments usually depend on equations assuming a pure regional flow which is straight and uniform. The most important goal of this undertaking was to develop extra reasonable equations for the advective part of contaminant transport, by together with the flow lines distortion occurring in the neighborhood of the injection well. The …

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